Systematic Review and Meta-Analysis of Complement Response to Burn Injury

Patrick P. G. Mulder's 2026 systematic review and meta-analysis synthesizes quantitative data on complement activation following burn injury. The work includes 110 studies, with 73 eligible for meta-analysis, covering human and animal studies with varied burn characteristics. It provides a time-dependent analysis of complement factors like C3a, C5a, and membrane attack complex from the immediate post-burn period to beyond 21 days.

Use Cases

• Modeling temporal dynamics of complement activation based on reported outcomes across predefined time intervals.
• Analyzing risk of bias in burn injury studies based on assessments using SYRCLE and ROBANS-II tools.
• Investigating heterogeneity in complement factor levels based on variations in burn size, depth, and etiology mentioned in the description.
• Synthesizing evidence for complement-targeted therapies based on the reported alterations in C3a, C5a, factor B, and membrane attack complex.

Strengths

• Includes quantitative synthesis from 73 studies eligible for meta-analysis.
• Provides longitudinal analysis across six predefined post-burn time intervals.
• Assesses risk of bias using established tools (SYRCLE and ROBANS-II).
• Released under a permissive CC-BY-4.0 license.

Limitations

• The primary data file is a 38.4 KB DOCX document, suggesting limited raw data scope.
• Row count and column-level documentation are absent; data structure must be inferred from the text.
• The included studies reportedly have substantial underreporting of methodological details, leading to unclear or high risk of bias.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of studies from PubMed and Embase searched on February 20, 2025.

Time Range

Studies likely cover a range of publication dates up to the search date in 2025.

Freshness

Last updated 2026-03 17 13:07:27.

Geography

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