Network Meta-Analysis of Vitamin D Combination Therapies for Pediatric Rickets

Ten randomized controlled trials involving 867 children compare nine vitamin D-based combination regimens against monotherapy. This supplementary document presents a Bayesian network meta-analysis evaluating efficacy and safety for nutritional rickets. The analysis was authored by Yunfeng Cao and published in April 2026.

Use Cases

• Compare serum 25-hydroxyvitamin D level improvements across nine different combination regimens.
• Analyze relative safety rankings based on adverse event risk data from included trials.
• Model outcome-specific advantages for term versus preterm infant subgroups using reported P-values.
• Validate network meta-analysis findings through described sensitivity analysis methods.

Strengths

• Analysis synthesizes data from 10 randomized controlled trials.
• Includes 867 pediatric patient records for comparative evaluation.
• Findings are supported by sensitivity analyses confirming robustness.

Limitations

• Small overall sample size of 867 children limits statistical power for some comparisons.
• Evidence base is constrained by the limited number (10) of available high-quality trials.
• Subgroup findings for term infants may not generalize to all pediatric populations.

Provenance

Source

Systematic review and network meta-analysis published on figshare.

Collection Method

Bayesian network meta-analysis of RCTs identified via systematic search of seven databases.

Time Range

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Freshness

Last updated in April 2026.

Geography

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