Supplementary File for Planet-Formation-Inspired Chemotherapy Dosing Model

A 8.8 MB DOCX file contains a study proposing a novel adaptive controller for chemotherapy dosing. The research, authored by Marco P. Soares dos Santos and uploaded to figshare in May 2026, uses planet-formation-inspired dynamics to manage tumor volumes of 200 and 2,000 mm³ under different resistance scenarios. Simulation results demonstrate the controller's performance against conventional methods.

Use Cases

• Developing adaptive chemotherapy dosing algorithms based on the described planet-formation-inspired controller.
• Simulating tumor dynamics under different initial volumes (200 and 2,000 mm³) and chemoresistance conditions.
• Analyzing the influence of controller parameters on treatment outcomes using Sobol indices.
• Comparing geometro-pharmacokinetic detumorization dynamics against non-adaptive intermittent administrations.

Strengths

• Includes simulation results for two distinct tumor volumes (200 and 2,000 mm³).
• Analyzes therapy with and without chemoresistance, covering a key clinical variable.
• Provides necessary stability conditions for the proposed controller.

Limitations

• The dataset is a single DOCX document; the underlying simulation data or code is not provided separately.
• Row count and column-level documentation are unknown, limiting suitability assessment.
• The description is detailed but the actual data files and their structure require manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely contains analytical derivations and results from in silico simulations.

Freshness

Last updated 2026-05-11 10:48:23.