SLC6A4 Promoter Methylation and Non-Suicidal Self-Injury in Adolescent Bipolar Depression

48 children and adolescent patients with bipolar depression were stratified by the presence of non-suicidal self-injury (NSSI) to investigate epigenetic associations. The dataset includes methylation levels for five CpG sites in the SLC6A4 promoter region, mRNA expression data, and scores from the Adolescent Self-Rating Life Events Checklist (ASLEC). This supplementary file, authored by Alimire Alimujiang and shared under CC-BY-4.0, was last updated in May 2026.

Use Cases

• Correlating specific CpG site methylation levels with mRNA expression based on pyrosequencing and qRT-PCR data
• Modeling risk factors for non-suicidal self-injury using logistic regression based on methylation and expression variables
• Investigating the role of stressful life events in adolescent psychopathology based on ASLEC scores

Strengths

• Includes data from a clinically defined cohort of 48 patients meeting ICD-10 criteria for bipolar depression
• Contains measurements for five specific CpG sites and mRNA expression, allowing for correlation analysis
• Shared under a permissive CC-BY-4.0 license, facilitating reuse

Limitations

• The small sample size of 48 individuals is noted by the authors as a limitation requiring replication
• Row count and column-level documentation are unknown, limiting suitability assessment
• Data is from a cross-sectional study design, which cannot establish causality

Provenance

Source

figshare

Collection Method

Patients were recruited and stratified into NSSI and non-NSSI groups; methylation was determined by pyrosequencing and mRNA expression by qRT-PCR.

Freshness

Last updated 2026-05-19 05:38:33