Pediatric Pneumonia Fluid Volume and Respiratory Risk, Single-Center Observational Study

243 children developed respiratory deterioration in a study linking intravenous fluid volume to clinical outcomes. This dataset likely contains results from a single-center observational study using electronic health record data to evaluate fluid-to-maintenance ratios and respiratory deterioration risk. The data was authored by Zhu Zhu and last updated on 2026-04-10.

Use Cases

• Modeling the association between fluid-to-maintenance ratio (FMR) and respiratory deterioration risk based on the described logistic regression analysis.
• Analyzing the dose-response relationship of IV fluid exposure using the reported quartile categorization and spline modeling.
• Conducting sensitivity analyses on fluid front-loading and physiological response as referenced in the description.
• Investigating the role of biomarkers like procalcitonin (PCT) in attenuating the fluid-deterioration association.

Strengths

• Study reports specific event rates across quartiles (3.1%, 6.1%, 9.6%, 21.2%).
• Analysis includes multiple statistical methods: multivariable logistic regression, restricted cubic splines, and overlap weighting.
• Results are supported by sensitivity analyses, including an early-response analysis and a repeated-measures time-slope analysis.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is from a single-center study, which may limit generalizability.

Provenance

Source

figshare

Collection Method

Single-center observational study using electronic health record data.

Time Range

The study uses a 24-hour landmark design and assesses outcomes between 24 and 72 hours.

Freshness

Last updated 2026-04-10 05:59:41; freshness should be verified.

Geography

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