CXCL12 Levels and Stroke Severity in a 134-Patient Prospective Cohort

A prospective cohort study of 134 ischemic stroke patients assessed within 6 hours of onset or with wake-up stroke. The dataset, authored by Fernando Ostos and last updated in May 2026, includes clinical data, plasma CXCL12 levels, and neutrophil phenotype measurements taken at admission, 24 hours, and 3 months post-stroke.

Use Cases

• Predicting hemorrhagic transformation risk based on 24-hour CXCL12 levels mentioned in the description
• Correlating admission biomarker levels with radiological severity (ASPECTS scores) and infarct volume
• Analyzing the relationship between cytokine levels and neutrophil extracellular trap (NET) markers
• Developing predictive models for acute stroke severity using backward stepwise regression as described

Strengths

• Data from 134 patients provides a defined cohort size for analysis
• Longitudinal measurements at three time points (admission, 24h, 3 months) enable temporal analysis
• Includes multiple clinical assessment scores (NIHSS, ASPECTS) and functional outcomes
• Published under a CC-BY-4.0 license for open reuse

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data may reflect bias inherent to a single, specific patient cohort

Provenance

Source

figshare

Collection Method

Prospective cohort study with clinical, laboratory, and radiological data collection.

Time Range

Patient assessments occurred at admission, 24 hours, and 3 months post-stroke.

Freshness

Last updated 2026-05-12 04:18:58; freshness should be verified