Supplementary file 1_CXCL8 greatly enhances neutrophil extracellular traps formation induc

A supplementary document detailing in vitro and in vivo experiments on neutrophil extracellular traps (NETs). The research by Irene Fasciani investigates how the chemokine CXCL8 amplifies NETosis induced by calcium carbonate and calcium pyrophosphate dihydrate crystals. The findings were last updated in April 2026.

Use Cases

• Analyze the cooperative effect of CXCL8 and calcium crystals on NET formation based on the described experimental results.
• Investigate signaling pathways in crystal-driven NETosis based on the described inhibition of Src kinases, PI3K, and ERK1/2.
• Study potential therapeutic targets for sterile inflammation based on the described concept of CXCR1/2 antagonists limiting pathological NET formation.
• Validate in vivo models of NETosis based on the described murine model measuring serum citrullinated histone H3.

Strengths

• Provides mechanistic insight into sterile inflammatory diseases including gout, pseudogout, atherosclerosis, and pancreatitis.
• Includes both in vitro (human neutrophils) and in vivo (murine model) experimental validation.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is a 672.2 KB DOCX file, which is a small supplementary document rather than a structured data repository.
• Column-level documentation and sample data are unavailable; data structure must be inferred from the document.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare, authored by Irene Fasciani.

Collection Method

Likely contains experimental data from laboratory studies on human neutrophils and a murine model.

Time Range

null

Freshness

Last updated 2026-04-20 05:20:13.

Geography

null