Rat Model Data for Senolytic Therapy in Radiation-Induced Lung Injury

232.5 KB of supplementary data from a study investigating dasatinib and quercetin therapy in a rat model of radiation-induced lung injury. The dataset includes results from histology, immunofluorescence, Western blotting, immunohistochemistry, and transcriptomic profiling. Author Jing Liu published the data under a CC-BY-4.0 license on figshare in March 2026.

Use Cases

• Analyze transcriptomic profiles to explore apoptotic pathway activation mentioned in the description
• Correlate histopathological changes with molecular markers of cellular senescence like p53 and p21
• Investigate the relationship between DNA damage (γH2AX levels) and senescence-associated secretory phenotype (SASP) factors
• Model the therapeutic effects of drug combinations on radiation-induced fibrosis and inflammation

Strengths

• Data is associated with a detailed experimental protocol using a single 30 Gy irradiation to establish the rat model.
• Includes multi-modal assessments: histology, immunofluorescence, Western blotting, immunohistochemistry, and transcriptomic profiling.
• Published under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 232.5 KB file size suggests a limited scope, likely containing summary results rather than raw sequencing data.

Provenance

Source

figshare

Collection Method

Data generated from a controlled laboratory study using a rat model of radiation-induced lung injury.

Freshness

Last updated 2026-03-18 07:38:30; freshness should be verified.