Fine-Wool Sheep Skin Single-Cell Atlas for Fiber Diameter Genetics

59,732 high-quality single cells from skin tissues of six half-sibling fine-wool sheep were sequenced and annotated into 14 distinct cell types. Tong Xiao published this transcriptional atlas of the hair follicle microenvironment on figshare in 2026. The data compares ultra-fine, medium-fine, and fine wool groups to uncover genetic underpinnings of fiber diameter.

Use Cases

• Identify differentially expressed genes across cell types based on wool fiber diameter groups mentioned in the description
• Analyze cell-cell communication networks based on ligand-receptor pairs involved in hair follicle regulation
• Reconstruct developmental trajectories of epidermal lineage cells using pseudotime analysis described in the study
• Validate gene function in dermal papilla cell proliferation based on CRABP1 overexpression experiments

Strengths

• 59,732 high-quality single cells provide a detailed cellular landscape
• Systematic annotation into 14 distinct cell types using known marker genes
• Includes data from six half-sibling sheep reared under identical conditions for controlled comparison

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data is stored in a DOCX file format, which may require extraction of underlying data tables

Provenance

Source

figshare

Collection Method

Single-cell RNA sequencing (scRNA-seq) performed on skin tissues from six half-sibling fine-wool sheep.

Freshness

Last updated 2026-06-01 05:25:36