Supplementary Data for Dendrobium Officinale Polysaccharide Study on NAFLD

A 2.7 MB DOCX file from figshare, authored by Binhong Hu and last updated in June 2026. The file contains supplementary data for a study exploring the therapeutic effect of Dendrobium officinale polysaccharide on high-fat diet-induced non-alcoholic fatty liver disease in rats. The research integrated transcriptomics, metabolomics, and 16S rRNA sequencing to investigate mechanisms involving the SIRT6/PGC-1α signaling axis and gut microbiota regulation.

Use Cases

• Validate findings on the SIRT6/PGC-1α signaling axis in lipid metabolism based on the described multi-omics analysis.
• Analyze correlations between gut microbiota composition (e.g., Lactobacillus abundance) and liver steatosis based on the 16S rRNA sequencing results.
• Benchmark therapeutic effects of polysaccharides on oxidative stress and lipid disorders using the described rat model data.
• Investigate glycerophospholipid metabolism pathways in the liver as indicated by the metabolomics results.

Strengths

• Data is associated with a multi-omics study integrating transcriptomics, metabolomics, and 16S rRNA sequencing.
• The underlying research includes in vitro validation using a SIRT6 inhibitor (OSS_128167) to confirm a key mechanism.
• The dataset is shared under a permissive CC-BY-4.0 license.

Limitations

• The dataset is a 2.7 MB DOCX file; the specific data format and structure are not described.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Data generated from a rat model study of NAFLD, utilizing multi-omics techniques and 16S rRNA sequencing.

Freshness

Last updated 2026-06-02 16:58:35; freshness should be verified.