Meta-Analysis Data on Interleukin-27 and C-Reactive Protein for Neonatal Sepsis Diagnosis

A systematic review and meta-analysis document evaluating the diagnostic performance of interleukin-27 (IL-27) versus C-reactive protein (CRP) for neonatal sepsis. The analysis includes five controlled studies involving 495 neonates, published from January 1996 to December 2025. The document was authored by Wei Liu and shared under a CC-BY-4.0 license.

Use Cases

• Comparing diagnostic accuracy of IL-27 and CRP based on pooled sensitivity and specificity metrics from the meta-analysis
• Evaluating the summary receiver operating characteristic (SROC) curves and area under the curve (AUC) values for both biomarkers
• Assessing the methodological quality and evidence synthesis of clinical studies on neonatal sepsis biomarkers

Strengths

• Analysis is based on five controlled studies involving 495 neonates, providing a defined sample size
• The study followed PRISMA guidelines and was prospectively registered in PROSPERO (CRD420251272080), suggesting structured methodology
• Pooled sensitivity (0.82) and specificity (0.85) for IL-27 are reported with 95% confidence intervals

Limitations

• The dataset is a 302.8 KB DOCX file, which is a small document format not structured as a typical data table
• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment for quantitative analysis

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of studies from PubMed, Embase, and Cochrane Library.

Time Range

Studies published from January 1996 to December 2025.

Freshness

Last updated 2026-05-13 05:35:47; freshness should be verified