Supplementary File 1: L-Arginine Supplementation Effects on Colitis and Gut Microbiota

7.8 MB document by Lerun Gong, last updated May 2026, describes a mouse model study on ulcerative colitis. The research investigates the prophylactic versus therapeutic effects of dietary L-arginine supplementation, analyzing body weight, disease activity, colon length, serum markers, inflammatory cytokines, and gut microbiota alterations via 16S rRNA sequencing and fecal microbiota transplantation.

Use Cases

• Analyzing the timing of dietary intervention efficacy based on comparisons of prophylactic versus therapeutic supplementation schedules.
• Studying gut microbial community structure alterations based on 16S rRNA sequencing data mentioned in the description.
• Investigating intestinal barrier function and inflammatory response based on serum lipopolysaccharide and cytokine (TNF-α, IFN-γ, IL-10) level measurements.
• Validating microbiome-mediated protective effects based on fecal microbiota transplantation (FMT) experiments described.

Strengths

• The description provides a detailed methodological breakdown of the mouse study, including intervention groups (BeArg, DuArg) and multiple evaluation endpoints.
• Data is shared under a permissive CC-BY-4.0 license, allowing for broad reuse.
• The 7.8 MB file size suggests the document contains substantial supplementary information beyond a simple abstract.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.
• The primary data format is DOCX, which may require parsing to extract structured data.

Provenance

Source

figshare

Collection Method

Likely contains supplementary data and results from a controlled laboratory mouse study.

Freshness

Last updated 2026-05-29 06:11:33; freshness should be verified.