Direct Dapagliflozin Effects on Cardiac Mitochondrial Function in Rats

Wistar rats (Rattus norvegicus) were the source for isolated cardiac mitochondria used to study the direct effects of dapagliflozin. The dataset, authored by Itanna Isis Araújo de Souza and last updated in May 2026, contains findings on oxygen consumption, ATP production, ROS generation, and membrane potential. It is shared under a CC-BY-4.0 license as a 1.9 MB DOCX file.

Use Cases

• Modeling mitochondrial bioenergetic efficiency based on ATP/ROS ratio changes
• Analyzing electron transport chain modulation based on differential effects on complexes I and II
• Investigating cardioprotective drug mechanisms based on mitochondrial membrane hyperpolarization data

Strengths

• Specific dapagliflozin concentration tested (10 nM)
• Systematic evaluation of multiple mitochondrial functions (oxygen consumption, ATP, ROS, membrane potential)
• Clear license (CC-BY-4.0) facilitating reuse

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download

Provenance

Source

Itanna Isis Araújo de Souza

Collection Method

Experimental data from isolated cardiac mitochondria exposed to dapagliflozin.

Freshness

Last updated 2026-05-01 04:17:18