Meta-Analysis of Direct Oral Anticoagulants vs. Warfarin for Left Ventricular Thrombus

Lama Alfehaid's systematic review and meta-analysis compares direct oral anticoagulants (DOACs) with vitamin K antagonists (VKAs) for treating left ventricular thrombus. The analysis includes 29 studies, comprising randomized controlled trials and observational cohorts, sourced from PubMed/MEDLINE, Embase, and Cochrane Central. The dataset, last updated on 2026-05-14, is a 1.1 MB DOCX file summarizing pooled risk ratios for outcomes like thrombus resolution, embolism, mortality, and bleeding.

Use Cases

• Compare the efficacy of DOACs versus VKAs based on the reported risk ratios for thrombus resolution.
• Assess the safety profile of anticoagulants based on the reported risk ratios for bleeding events.
• Evaluate the association between anticoagulant type and all-cause mortality based on the meta-analysis results.
• Inform clinical trial design based on the identified evidence gaps and heterogeneity metrics.

Strengths

• Includes 29 studies, providing a substantial evidence base for the meta-analysis.
• Reports specific pooled risk ratios with 95% confidence intervals and I² statistics for heterogeneity.
• Systematic review protocol is registered with PROSPERO (CRD420251181379).

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Lama Alfehaid

Collection Method

Systematic review and meta-analysis of studies from PubMed/MEDLINE, Embase, and Cochrane Central.

Time Range

Studies searched from database inception through the most recent search date.

Freshness

Last updated 2026-05-14 05:23:26; freshness should be verified.