Metabolomic Data on Anti-Inflammatory Phenanthrenes from Oreorchis Patens

A 4.7 MB supplementary document details the metabolomic investigation of the edible plant Oreorchis patens. The study identified six phenanthrene derivatives, including two monomers and four dimers, and characterized their anti-inflammatory activity. Author Fan Wei published the findings in March 2026 under a CC BY 4.0 license.

Use Cases

• Analyze the planar structures and absolute configurations of six identified phenanthrene derivatives using NMR and ECD data.
• Investigate the anti-inflammatory activity of phenanthrene dimer 3 in lipopolysaccharide-stimulated MH-S macrophages.
• Study the binding interaction between compound 3 and the allosteric site of AMPK to understand its mechanism of action.
• Examine the subsequent regulation of NF-κB signaling by activated AMPK as detailed in the mechanistic insights.

Strengths

• Data is derived from a metabolomic investigation of a plant classified in China as having food and medicine homology.
• Includes characterization of six specific bioactive compounds, with two monomers and four dimers identified.
• Findings are supported by multiple analytical methods including NMR spectroscopy, electronic circular dichroism, and computational chemistry.

Limitations

• The dataset is a 4.7 MB DOCX file, limiting direct computational analysis and requiring manual extraction of tabular or structured data.
• Sample data and column definitions are unavailable, obscuring the specific variables and measurements recorded.
• The data scope is confined to the specific compounds and biological assays described, not a broad screening.

Provenance

Source

Figshare, authored by Fan Wei.

Collection Method

Metabolomic investigation of Oreorchis patens edible parts, with compound identification via NMR spectroscopy and electronic circular dichroism.

Freshness

Last updated March 2026.

Geography

Study involves a plant classified in China as having food and medicine homology.