SGLT2 Inhibitor Discovery Data for Diabetic Nephropathy Treatment

Supplementary file 1 from figshare contains experimental data on novel sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors. The dataset includes in vitro IC50 values, selectivity ratios, and in vivo treatment results from a study by Haotian Ni, published in April 2026. It documents a virtual screening approach that identified compounds with nanomolar potency.

Use Cases

• Analyze IC50 values to rank compound potency against SGLT2.
• Compare SGLT1/SGLT2 selectivity ratios to assess target specificity.
• Evaluate in vivo results on renal glucose excretion and blood glucose reduction.
• Study the integrated virtual screening methodology combining pharmacophore modeling and docking.

Strengths

• Reports highly potent compounds with IC50 values as low as 1.5 nM.
• Includes a high selectivity ratio of 3510-fold for a primary hit.

Limitations

• Dataset scope is limited to a single study's findings at 345.8 KB.
• Unknown row count and specific column structure within the DOCX file.

Provenance

Source

figshare, author Haotian Ni.

Collection Method

Integrated virtual screening and in vitro/in vivo experimental validation.

Time Range

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Freshness

Last updated April 2026.

Geography

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