Experimental Autoimmune Myasthenia Gravis Rat Data on Gut Microbiota and Immune Markers

A 290.7 KB supplementary PDF file from a 2026 study by Wenqi Tian, published on figshare under CC-BY-4.0. The data likely contains measurements from Lewis rats used to model myasthenia gravis, including serum cytokine levels, antibody titers, and gut microbiota sequencing results.

Use Cases

• Correlating gut microbiota composition changes with disease severity based on 16S rRNA sequencing data.
• Modeling the relationship between serum inflammatory markers (IFN-γ, TNF-α, IL-17, IL-10) and clinical outcomes.
• Investigating intestinal barrier integrity via Claudin-1 and Muc2 protein level measurements.
• Analyzing the impact of fecal microbiota transplantation on immune cell populations (Th17/Treg) quantified by flow cytometry.

Strengths

• Data is associated with a peer-reviewed scientific study with a detailed methodological description.
• Includes multiple biological measurement types (cytokines, antibodies, microbiota, histology) for integrative analysis.
• Licensed under CC-BY-4.0, permitting broad reuse with attribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 290.7 KB file size suggests a limited scope, likely containing summary or supplementary data rather than raw datasets.

Provenance

Source

figshare, author Wenqi Tian.

Collection Method

Data generated from an experimental autoimmune myasthenia gravis (EAMG) model in Lewis rats, using methods including 16S rRNA sequencing, ELISA, immunofluorescence, and flow cytometry.

Time Range

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Freshness

Last updated 2026-04-10 05:29:20; freshness should be verified.

Geography

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