Supplementary File 1: Dopamine Receptor Roles in HIV Latency Reversal in Myeloid Cells

A 39.6 KB PDF details a study investigating how dopamine receptors DRD1 and DRD4 contribute to HIV latency reversal in a myeloid cell model. Authored by Liana V. Basova and published on figshare in May 2026, the work uses single-cell approaches to identify signaling pathways and cell phenotypes associated with viral transcription. The findings suggest latency reversal involves diverse inflammatory pathways with cell activation as a common feature.

Use Cases

• Analyze signaling pathways involved in HIV latency reversal based on the description of dopamine receptor activation.
• Identify cell phenotypes associated with positive HIV transcription based on the single-cell approach described.
• Study cross-regulation between dopamine receptors DRD1 and DRD4 based on the reported cluster and gene perturbation analysis.
• Investigate the role of inflammatory pathways in neuroimmune interactions as suggested by the discussion of convergent signatures.

Strengths

• Data is openly licensed under CC-BY-4.0, permitting reuse with attribution.
• The study employs a specific single-cell approach to identify cell phenotypes, as described in the methods.

Limitations

• The dataset is a 39.6 KB PDF, which is a small supplementary document rather than a primary data repository.
• Row count and column-level data are unknown, limiting suitability assessment for computational analysis.
• The description lacks specifics on the underlying experimental data's structure or availability.

Provenance

Source

figshare, authored by Liana V. Basova.

Collection Method

Likely contains experimental results from a study using selective dopamine receptor agonists and single-cell analysis in a myeloid cell model.

Freshness

Last updated 2026-05-28 04:52:37.