Donepezil Ameliorates Fatigue and Depression in PASC Patients: Supplementary File

156 PASC patients were assessed for serum anti-SITH-1 antibody titers, with 62.8% testing positive. Naomi Oka authored this supplementary document, which details findings from a mouse model and a clinical trial subgroup analysis of 73 patients. The file was last updated on June 4, 2026.

Use Cases

• Analyze the association between anti-SITH-1 antibody status and symptom severity based on the described clinical cohort.
• Investigate the potential therapeutic effect of donepezil based on the described clinical trial subgroup analysis.
• Study the proposed link between HHV-6B reactivation and acetylcholine deficiency based on the described mouse model findings.

Strengths

• The description provides specific quantitative results, including a sample size of 156 patients and a seropositivity rate of 62.8%.
• The document references a clinical trial subgroup analysis involving 73 PASC patients, providing a basis for evaluating a potential treatment effect.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The data is contained within a 515.9 KB DOCX file, indicating a limited scope likely focused on supplementary text and analysis.

Provenance

Source

figshare

Collection Method

Likely contains supplementary text, figures, and tables from the associated research study.

Freshness

Last updated 2026-06-04 05:18:58; freshness should be verified.