Esketamine Adverse Events Meta-Analysis for Treatment-Resistant Depression

Nine randomized controlled trials involving 1,449 patients were included in this systematic review and meta-analysis. The study, authored by Yang Qu and published on figshare in 2026, evaluates the dose-dependent safety profile of esketamine for treatment-resistant depression. It found esketamine significantly increased the risk of nine adverse events, including nausea and dissociation, with risks strongly dose-dependent.

Use Cases

• Assess dose-dependent risk profiles for adverse events based on dosage ranges (28-84 mg nasal spray, 0.20-0.40 mg/kg intravenous).
• Compare adverse event incidence between geographic regions based on subgroup analysis of Mainland China versus International multi-regional studies.
• Inform precision dosing strategies based on the analysis of efficacy versus tolerability trade-offs.
• Validate meta-analysis findings against new clinical trial data based on the systematic review methodology.

Strengths

• Analysis is based on 9 randomized controlled trials, a standard for clinical evidence.
• Includes 1,449 patient records, providing a substantive sample size for meta-analysis.
• Performs subgroup analyses by dosage, administration route, and geographic region, adding analytical depth.

Limitations

• The dataset is a 12.0 KB DOCX file, indicating limited raw data scope; likely contains summary results rather than patient-level records.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect publication bias inherent to systematic reviews of published trials.

Provenance

Source

Systematic review and meta-analysis of trials from PubMed, Embase, Cochrane Library, CBM, CNKI, and Wanfang databases.

Collection Method

Literature search and statistical meta-analysis conducted using RevMan 5.4.1.

Time Range

Literature searched from database inception to March 2025.

Freshness

Last updated 2026-05-28 06:23:31; freshness should be verified.

Geography

Studies from Mainland China and International multi-regional sources.