Supplementary file 1_Drug-drug interactions between sex hormones and analgesics linked to

15.9 million reports from the FDA Adverse Event Reporting System (FAERS) were analyzed for drug-drug interactions between sex hormones and analgesics linked to thromboembolic events. The study identified 162,846 venous thromboembolism (VTE) and 283,197 arterial thromboembolism (ATE) cases, with thirteen drug pairs showing positive DDI signals for VTE. This dataset, authored by Seiki Yamazaki and last updated in April 2026, supports pharmacovigilance research.

Use Cases

• Signal detection for drug-drug interactions based on disproportionality analysis methods described in the study
• Investigating sex-specific differences in thromboembolic risk associated with concomitant medication use
• Validating spontaneous reporting system findings against existing epidemiological data on thrombosis
• Analyzing reporting patterns for venous and arterial thromboembolism events in a large adverse event database

Strengths

• Analysis is based on 15.9 million adverse event reports, providing a large sample size
• Results include specific case counts: 162,846 VTE and 283,197 ATE events
• Uses four complementary statistical methods for DDI signal detection

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download
• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

Food and Drug Administration Adverse Event Reporting System (FAERS)

Collection Method

Disproportionality analysis using crude reporting odds ratios and DDI signal detection

Freshness

Last updated 2026-04-21 05:35:13; freshness should be verified