Paeonia Lactiflora Extract Effects on Uric Acid in Rat Models

A 2.9 MB PDF research article details the dual mechanisms of a purified root extract (PLE-2) in regulating uric acid homeostasis. The study, authored by Tingting Jin and last updated in April 2026, presents in vitro and in vivo results from hyperuricemic rat models treated with three dose levels (100, 200, and 400 mg/kg).

Use Cases

• Analyze dose-response relationships between PLE-2 administration levels (100, 200, 400 mg/kg) and serum uric acid, creatinine, and blood urea nitrogen measurements.
• Model the correlation between molecular docking scores for paeoniflorin binding and the expression levels of target proteins (XOD, ADA, URAT1, GLUT9, OAT1, OAT3, ABCG2) from qPCR and Western blot data.
• Compare the efficacy of PLE-2 against allopurinol by evaluating the reported ranges for reduced serum uric acid levels and improved kidney histology scores.

Strengths

• Detailed mechanistic data includes quantitative results for 7 key transporter and enzyme targets (XOD, ADA, URAT1, GLUT9, OAT1, OAT3, ABCG2).
• Experimental design includes three distinct dose levels (100, 200, 400 mg/kg) and a positive control (allopurinol) for comparative analysis.

Limitations

• Dataset is a single 2.9 MB PDF; underlying raw numerical data, sample sizes, and exact row counts for measurements are not provided.
• Findings are specific to a potassium oxonate/hypoxanthine-induced rat model, limiting direct extrapolation to human physiology.

Provenance

Source

Figshare, authored by Tingting Jin.

Collection Method

Data generated from in vitro HK-2 cell assays and in vivo experiments using a chemically-induced hyperuricemic rat model.

Freshness

Last updated in April 2026, indicating recent research.