Earthworm Extract Study: Preclinical Data on Colitis Treatment via PI3K/AKT Pathway

Supplementary data from a preclinical study investigating earthworm extract as a treatment for ulcerative colitis. The dataset includes results from murine models and Caco-2 cell line experiments, analyzing cytokine levels, intestinal permeability, and protein expression. The work was authored by Shaoru Zhang and last updated on 2026-05-29.

Use Cases

• Validate the anti-inflammatory effects of earthworm extract based on cytokine suppression data mentioned in the description
• Study the restoration of intestinal barrier integrity based on tight junction protein expression results
• Investigate the PI3K/AKT signaling pathway as a therapeutic target based on network pharmacology and validation experiments
• Characterize bioactive macromolecular components based on heat inactivation and dialysis fractionation studies

Strengths

• Dataset is licensed under CC-BY-4.0, permitting broad reuse with attribution.
• The description provides a detailed methodological account of in vivo and in vitro validation.

Limitations

• The dataset is a 6.8 MB DOCX file, which is a small and non-standard format for structured data analysis.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Shaoru Zhang via figshare

Collection Method

Data generated from murine colitis models and Caco-2 cell line experiments using techniques including ELISA, qRT-PCR, and western blotting.

Freshness

Last updated 2026-05-29 04:49:07; freshness should be verified.