Supplementary file 1_Effect of acupuncture on monoaminergic neurotransmitters in animal mo

Nine studies involving 386 rodents were included in this preclinical systematic review and meta-analysis. The document, authored by Lixiang Gan and last updated in May 2026, synthesizes evidence on the effect of acupuncture on monoaminergic neurotransmitter levels in animal models of vascular dementia. It reports standardized mean differences for serotonin, norepinephrine, dopamine, acetylcholine, long-term potentiation, and behavioral outcomes.

Use Cases

• Conducting secondary analysis of effect sizes for acupuncture on neurotransmitter levels based on the reported SMDs.
• Informing the design of future animal studies on vascular dementia based on the identified heterogeneity and sample sizes.
• Supporting literature reviews on complementary therapies for cognitive impairment using the synthesized results from nine studies.

Strengths

• Follows PRISMA 2020 guidelines and includes a PROSPERO registration (CRD420251179267), indicating a structured review process.
• Reports specific quantitative outcomes, including standardized mean differences for five key neurochemical and behavioral measures.

Limitations

• The dataset is a 23.7 KB DOCX file containing a review article, not a primary data table; column-level documentation is absent.
• Row count is unknown, which may limit suitability assessment for direct data analysis.

Provenance

Source

Lixiang Gan

Collection Method

Systematic review and meta-analysis of randomized controlled animal studies identified from eight English and Chinese databases.

Time Range

Literature search conducted from database inception to October 2025.

Freshness

Last updated 2026-05-11 04:24:33; freshness should be verified.