Meta-Analysis of Compression Stockings for Post-Thrombotic Syndrome Prevention

Eight randomized controlled trials involving 1,775 patients were analyzed to evaluate the effectiveness of elastic compression stockings (ECS) in preventing post-thrombotic syndrome (PTS) after deep vein thrombosis (DVT). The analysis, conducted by Yuanjie Duan and published on figshare in May 2026, pooled risk ratios and assessed evidence certainty using the GRADE approach. It found ECS were associated with a modest reduction in total and mild-to-moderate PTS, but effects on severe PTS, recurrent DVT, and mortality were uncertain.

Use Cases

• Evaluating the effectiveness of elastic compression stockings for PTS prevention based on pooled results from 8 RCTs.
• Assessing the certainty of evidence for different PTS severity outcomes using the GRADE framework described.
• Investigating heterogeneity in trial outcomes based on factors like adherence and control group design mentioned in the results.

Strengths

• Analysis is based on 8 randomized controlled trials, a standard for clinical evidence.
• Includes data from 1,775 patients, providing a substantive sample size for the meta-analysis.
• Uses the GRADE approach to assess evidence certainty, a recognized methodological framework.

Limitations

• The dataset is a 26.5 KB DOCX file, which is a very small document likely containing summary text rather than raw trial data.
• Row count and column-level documentation are unknown, limiting assessment of the underlying data structure.
• The description notes heterogeneity in adherence, control group design, and PTS definitions across trials, which may affect result generalizability.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of randomized controlled trials.

Time Range

Trials searched from database inception to January 20, 2026.

Freshness

Last updated 2026-05-21 04:31:21.