Systematic Review and Meta-Analysis of Cognitive-Motor Interventions on BDNF Post-Stroke

A systematic review and meta-analysis synthesizes evidence from nine randomized controlled trials involving 457 participants. The analysis, conducted by Edgar Vásquez-Carrasco and registered in PROSPERO, quantifies the effect of cognitive-motor rehabilitation on serum brain-derived neurotrophic factor levels in adults and older adults after stroke. The findings, published on figshare in May 2026, indicate a statistically significant, large overall effect.

Use Cases

• Conducting secondary meta-analyses on neuroplasticity biomarkers based on the aggregated effect size data.
• Designing new clinical trials for stroke rehabilitation based on the synthesized evidence from nine included studies.
• Evaluating the heterogeneity of treatment effects in neurorehabilitation based on the reported high I² statistic of 92%.
• Assessing methodological quality of stroke rehabilitation studies using the referenced PRISMA, RoB 2, and GRADE frameworks.

Strengths

• The meta-analysis is based on nine randomized controlled trials, a standard for high-quality evidence synthesis.
• The protocol was pre-registered in PROSPERO (CRD420251140852), enhancing transparency and reducing bias.
• The analysis reports a specific, large effect size (Hedges’ g = 2.51) with confidence intervals and p-value.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is a 681.8 KB document file; the underlying extracted data tables are not provided as a separate, machine-readable format.
• The description notes very high heterogeneity (I² = 92%) across the included studies, which complicates interpretation of the pooled effect.

Provenance

Source

figshare

Collection Method

Systematic literature review and meta-analysis of randomized controlled trials from multiple databases.

Freshness

Last updated 2026-05-07 05:42:50; freshness should be verified.