Flavonoid Effects on Atherosclerosis in ApoE Mice: A Systematic Review and Meta-Analysis

A 2026 systematic review and meta-analysis by Peiqi Gao synthesizes findings from 11 preclinical studies on flavonoids and atherosclerosis. The analysis, published on figshare, includes data on lipid markers and aortic plaque area in male ApoE−/− mice. It is available as a 76.5 KB DOCX file under a CC-BY-4.0 license.

Use Cases

• Conducting a secondary meta-analysis based on the synthesized lipid and plaque area data.
• Reviewing methodological quality and bias in preclinical flavonoid studies based on the systematic review framework.
• Identifying potential mechanisms of action for flavonoids based on the reported antioxidant and anti-inflammatory pathways.
• Designing future animal studies based on the identified gaps in standardization and publication bias.

Strengths

• Includes a meta-analysis of 11 studies, providing a quantitative synthesis of preclinical evidence.
• Reports specific findings on four key lipid markers (LDL-C, TC, TG, HDL-C) and aortic plaque area.
• Conducted sensitivity, subgroup, and publication bias analyses, as described in the methodology.

Limitations

• The dataset is a 76.5 KB DOCX document; the underlying tabular meta-analysis data is not provided in a structured, machine-readable format.
• Row count and column-level documentation for any extracted data are unknown.
• The description notes high heterogeneity (I² ≥ 75%) and potential publication bias in the included studies.

Provenance

Source

figshare, author Peiqi Gao.

Collection Method

Systematic review and meta-analysis of literature from databases including PubMed and Web of Science.

Freshness

Last updated 2026-05-29 06:15:03.