Meta-Analysis of Interventions for Muscle Mass and Metabolism in Chronic Kidney Disease
by Shuilian Leng·Updated 2mo ago
2.8 MB1files
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Description
22 clinical studies from inception to July 1, 2025, involving 2,879 patients with chronic kidney disease, are analyzed in this systematic review and network meta-analysis. The work, authored by Shuilian Leng and published in April 2026, compares the effects of sodium bicarbonate, cholecalciferol, and protein supplementation on muscle mass and metabolic parameters.
Use Cases
Rank intervention efficacy using SUCRA values for outcomes like serum phosphorus reduction and adverse event incidence.
Compare standardized mean difference (SMD) and confidence interval data for muscle mass changes across cholecalciferol, sodium bicarbonate, and protein supplementation arms.
Analyze heterogeneity and effect sizes from 11 sodium bicarbonate, 5 cholecalciferol, and 6 protein supplementation studies for protocol design.
Validate meta-analysis findings on serum albumin improvement (SMD=0.50) and bicarbonate/potassium level changes against new clinical trial data.
Strengths
Includes 22 studies with a total patient population of 2,879 for pooled analysis.
Provides specific effect metrics like SMD values and 95% confidence intervals for key outcomes such as muscle mass and serum albumin.
Employs both conventional and network meta-analysis with SUCRA ranking for a multi-intervention comparison.
Limitations
Small sample sizes and limited number of included studies per intervention category (e.g., only 5 cholecalciferol studies) reduce statistical power.
Substantial heterogeneity in intervention protocols across studies may affect result generalizability.
The 2.8 MB DOCX file contains textual analysis results, not raw patient-level data, limiting direct computational reuse.
Provenance
Source
Systematic review and network meta-analysis published on figshare by author Shuilian Leng.
Collection Method
Systematic search of PubMed, Embase, Web of Science, and Cochrane Library; data extracted from eligible comparative clinical studies.
Time Range
Literature from database inception to July 1, 2025.
Freshness
Last updated April 2026, with literature search current to July 1, 2025.
Geography
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Data is presented as a DOCX document containing the review's textual results and statistical summaries, not as a structured data table; license is CC-BY-4.0.