Zishen Yutai Pill Effects on IVF Outcomes: Meta-Analysis of 18 RCTs

A systematic review and meta-analysis document evaluating the effects of the Chinese polyherbal preparation Zishen Yutai Pill on pregnancy outcomes for women undergoing in vitro fertilization. The analysis includes 18 randomized controlled trials with 5,660 participants, synthesizing evidence on clinical pregnancy, live birth, and miscarriage rates. The document was authored by Haifeng Wu and uploaded to figshare in April 2026.

Use Cases

• Systematic review replication based on the described methodology and included studies.
• Evidence grading for clinical guidelines based on the GRADE assessment of very low certainty evidence.
• Publication bias assessment based on the described use of funnel plots and Egger's test.
• Sensitivity analysis for meta-analytic results based on the described statistical approach.

Strengths

• Includes data from 18 randomized controlled trials with a total of 5,660 participants.
• Reports specific effect sizes (Risk Ratios and Mean Differences) with 95% confidence intervals for multiple outcomes.
• Adheres to a registered protocol (PROSPERO CRD420251030089).
• Includes a detailed safety analysis from 4 studies covering 589 participants.

Limitations

• The primary data file is a DOCX document (18.2 KB); the underlying tabular data for the meta-analysis is not provided as a separate, machine-readable dataset.
• The GRADE assessment indicated the quality of evidence for all outcomes was very low.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Systematic review of electronic databases (PubMed, Cochrane Library, Embase, Web of Science, CNKI, Wanfang, VIP, CBM).

Collection Method

Meta-analysis of randomized controlled trials using Review Manager 5.3 and Stata 17.0.

Time Range

Literature searched from database inception to 12 February 2025.

Freshness

Last updated 2026-04-23 05:34:48; freshness should be verified.