Supplementary file 1_Effects of traditional Chinese medicine polysaccharides on rheumatoid

A systematic review analyzing nine animal studies on the effects of Traditional Chinese Medicine polysaccharides (TCMPs) on rheumatoid arthritis. The review, conducted by Suhai Qian and published on figshare in 2026, synthesizes findings from 282 initially identified records. It reports changes in 9 microbial phyla and 65 genera, correlating them with clinical outcomes and metabolic shifts.

Use Cases

• Meta-analysis of gut microbiota changes based on reported shifts in 9 phyla and 65 genera.
• Correlation studies between microbial taxa and disease severity based on reported negative associations for Romboutsia and Lactobacillus.
• Investigating therapeutic mechanisms based on described pathways like NF-κB, JAK/STAT3, and NLRP3 inflammasome modulation.
• Reviewing evidence for short-chain fatty acid (SCFA) roles in autoimmune conditions based on reported elevated butyrate and propionate levels.

Strengths

• Follows PRISMA guidelines for systematic review methodology.
• Quantifies results from 9 included studies, detailing changes in 9 microbial phyla and 65 genera.
• Includes a PROSPERO registration identifier (CRD420251053482) for protocol transparency.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The review notes low methodological quality and high heterogeneity among the included primary studies.
• Data is limited to animal models, which may not directly translate to human clinical outcomes.

Provenance

Source

figshare, author Suhai Qian.

Collection Method

Systematic literature review of PubMed, Web of Science, and Embase up to April 7, 2025.

Time Range

Literature search covered studies up to April 7, 2025.

Freshness

Last updated 2026-04-23 05:35:14; freshness should be verified.