Kai-xin-san Efficacy in Alzheimer's Animal Models: A Systematic Review and Meta-Analysis

A systematic review and meta-analysis of preclinical studies investigating the Chinese herbal formula Kai-xin-san for Alzheimer's disease. The analysis includes 44 studies involving 2,681 animals, assessing behavioral tests and biomarkers. The work was authored by Yuzhi Wang and uploaded to figshare in April 2026.

Use Cases

• Conducting secondary analysis of preclinical efficacy data based on the reported behavioral test results.
• Investigating multi-target therapeutic mechanisms based on the described biomarker data for Aβ, tau, inflammation, and oxidative stress.
• Assessing methodological quality and risk of bias in animal studies of Alzheimer's disease based on the described SYRCLE tool application.

Strengths

• Includes data from 44 distinct preclinical studies.
• Aggregates results from 2,681 animal subjects.
• Assesses efficacy across 3 behavioral tests and 9 specific biomarkers.

Limitations

• The primary data file is a 5.5 MB DOCX document; the underlying structured data (e.g., raw study results) is not directly available in a machine-readable format.
• The review notes a high risk of bias in the included studies, suggesting reported effect sizes may be inflated.
• Row count and column-level documentation for any underlying data tables are unknown.

Provenance

Source

figshare, author Yuzhi Wang.

Collection Method

Systematic search of 7 databases from inception to October 2025, followed by meta-analysis using STATA and RevMan software.

Time Range

Literature search covered studies from database inception to October 2025.

Freshness

Last updated 2026-04-23 05:35:12