Meta-Analysis of Direct Oral Anticoagulants in Pediatric Patients

A systematic review and meta-analysis synthesizes evidence from eight randomized controlled trials involving 2,002 pediatric patients. Siyi You authored this work, which was updated in April 2026. It compares the efficacy and safety of direct oral anticoagulants against standard of care for thromboembolism treatment and prophylaxis.

Use Cases

• Compare risk ratios for thromboembolism recurrence and major bleeding between DOACs and SOC using extracted trial data.
• Analyze pooled efficacy outcomes like TE occurrence in prophylaxis studies from synthesized results tables.
• Validate safety profiles by examining confidence intervals for serious adverse events and all-cause mortality across included RCTs.
• Replicate meta-analysis methodology using the search strategy details from PubMed, Embase, and ClinicalTrials.gov.
• Assess trial heterogeneity and effect sizes reported in forest plots or result summaries within the document.

Strengths

• Evidence synthesized from 8 randomized controlled trials, a standard for high-quality clinical reviews.
• Includes data from 2,002 pediatric patients, providing a substantial sample for this specialized population.
• Reports specific risk ratios with 95% confidence intervals for key efficacy and safety outcomes.
• Follows a registered, reproducible methodology (PROSPERO CRD42024506541).

Limitations

• The dataset is a 3.1 MB DOCX file containing narrative text and tables, not structured data, limiting computational analysis.
• Sample size is moderate for a pediatric meta-analysis, potentially limiting subgroup analyses.
• Temporal coverage of included trials is not specified, which may affect relevance to current clinical practice.

Provenance

Source

Systematic review conducted by author Siyi You, sourced from figshare.

Collection Method

Data synthesized from PubMed, Embase, Web of Science, and ClinicalTrials.gov using fixed- or random-effects models.

Time Range

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Freshness

Literature search conducted up to November 2025; document last updated April 2026.

Geography

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