Supplementary file 1_Efficacy of Bifidobacterium lactis BLa80 in preventing early childhoo

360 formula-fed infants and children under 3 years old with elevated allergy risk participated in a randomized, double-blind, placebo-controlled trial. The dataset likely contains results from a 180-day intervention assessing eczema incidence, respiratory infections, gut microbiota composition, and fecal immune markers. Author Ke Chen published the data on figshare under a CC-BY-4.0 license, with a last update in May 2026.

Use Cases

• Analyze the efficacy of Bifidobacterium lactis BLa80 in reducing eczema incidence based on the reported 27.6% vs. 69.5% incidence rates.
• Investigate correlations between gut microbiome composition and clinical outcomes based on 16S rRNA sequencing and KEGG pathway analysis mentioned in the description.
• Model the relationship between fecal immune markers like secretory IgA and calprotectin and symptom burden for upper respiratory tract infections.
• Study the enrichment of specific beneficial taxa such as Akkermansia and Fusicatenibacter in relation to probiotic supplementation.

Strengths

• Data originates from a randomized, double-blind, placebo-controlled trial with 360 participants, a robust study design.
• Includes multiple outcome measures: primary (eczema incidence), secondary (respiratory infections), and exploratory (microbiota, immune markers).
• Clinical trial is registered (ChiCTR2300074956), providing a traceable reference.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analyses.
• The 3.8 MB file size suggests the dataset is relatively small, potentially limiting the scope of analysis.

Provenance

Source

figshare, author Ke Chen.

Collection Method

Data collected from a randomized, double-blind, placebo-controlled clinical trial.

Time Range

The trial intervention lasted 180 days; specific study dates are not provided.

Freshness

Last updated 2026-05-28 15:54:30; freshness should be verified.