Efficacy of Immunotherapy and Targeted Therapy for Unresectable Hepatocellular Carcinoma

A pooled analysis of reconstructed individual patient data from 15 randomized controlled trials for unresectable hepatocellular carcinoma (uHCC). The data was digitized from Kaplan-Meier curves and analyzed using parametric survival models within a Bayesian framework to estimate time-dependent hazard ratios and survival probabilities. The dataset was created by Wan Zhou and last updated on April 23, 2026.

Use Cases

• Compare survival probabilities of different first-line therapies based on the pooled parametric models.
• Assess time-dependent hazard ratios for immunotherapy and targeted therapy regimens.
• Validate parametric survival models against conventional constant hazard ratio approaches.
• Benchmark the efficacy of combination therapies versus monotherapies for uHCC.

Strengths

• Analysis includes data from 15 randomized controlled trials.
• Uses a Bayesian framework for pooled parametric survival modeling.
• Data is licensed under CC-BY-4.0 for open reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Long-term comparisons depend partly on extrapolated estimates, as noted in the conclusion.

Provenance

Source

Systematic literature search of PubMed, Embase, and the Cochrane Library.

Collection Method

Individual patient data reconstructed from published Kaplan-Meier curves using digitization methods.

Freshness

Last updated 2026-04-23 05:32:40; freshness should be verified.