Meta-Analysis of Stem Cell Therapy for Achilles Tendon Rupture in Rat Models

Twenty-seven studies on rat models of Achilles tendon rupture were systematically reviewed and meta-analyzed. The data, compiled by Bingbing Li and published on figshare under a CC-BY-4.0 license, assesses the efficacy of stem cell transplantation on biomechanical and histological outcomes. The file was last updated on June 1, 2026.

Use Cases

• Assess the overall efficacy of stem cell therapy for tendon regeneration based on pooled results from 27 studies
• Investigate the time-dependent and dose-response patterns of stem cell treatment mentioned in the analysis
• Compare the effectiveness of scaffold-loaded stem cell strategies versus scaffold treatment alone as described in the results
• Evaluate methodological reporting quality and risk of bias in preclinical animal studies on this topic

Strengths

• Systematic review and meta-analysis based on 27 identified studies
• Includes subgroup analyses on factors like stem cell dose and time points
• Explicitly assesses risk of bias and publication bias in the included literature

Limitations

• The 15.8 MB file is a DOCX document; the underlying structured data (e.g., individual study data) is not provided in a machine-readable format
• Column-level documentation is absent; field semantics must be inferred from the document text
• The findings are based solely on rat models, which may limit direct translation to other species or humans

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of studies from PubMed, Web of Science, Embase, and Scopus.

Freshness

Last updated 2026-06-01 05:23:28; freshness should be verified