PTK6 Expression and Immune Microenvironment Data for Endometrial Carcinoma

A supplementary research file analyzing PTK6 expression in Uterine Corpus Endometrial Carcinoma (UCEC). The data includes multi-omics analysis from TCGA, GEO, and CPTAC sources, with immunohistochemistry validation on 200 samples. Author Zebiao Ma published the file on figshare under a CC-BY-4.0 license, last updated on June 3, 2026.

Use Cases

• Investigating the association between PTK6 expression and patient survival based on reported hazard ratios (HR=2.065, HR=8.562).
• Analyzing tumor microenvironment remodeling based on features like immune infiltration scores (ESTIMATE, TIMER3) and immunophenoscore (IPS).
• Studying molecular subtypes (MSI-H, POLE) in relation to gene expression and methylation (median β: 0.32 vs. 0.52).
• Validating PTK6 as a potential biomarker for immunotherapy optimization based on its link to PD-1/PD-L1 pathways.

Strengths

• Includes multi-omics data from established sources like TCGA, GEO, and CPTAC.
• Validation performed with a cohort of 200 samples via immunohistochemistry.
• Analysis links PTK6 to specific molecular subtypes (MSI-H) and clinical outcomes with reported p-values (p<0.001).

Limitations

• The dataset is a 46.9 KB DOCX file, suggesting limited raw data and likely containing summarized results or a manuscript.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for direct computational analysis.

Provenance

Source

TCGA, GEO, CPTAC databases, and author-collected IHC samples.

Collection Method

Multi-omics analysis, bioinformatics tools (ESTIMATE, TIMER3, TCIA), and immunohistochemistry validation.

Freshness

Last updated 2026-06-03 06:08:23; freshness should be verified.