Supplementary file 1_Endothelial glycocalyx injury in bacterial bloodstream infection: bio

Plasma biomarker and whole-blood transcriptome data from 188 intensive care unit patients with bacterial bloodstream infection. The dataset includes measurements of 24 plasma biomarkers, including syndecan-1 for glycocalyx degradation, and is associated with 30-day mortality outcomes. It was authored by Hui Wang and last updated in June 2026.

Use Cases

• Predicting 30-day mortality in ICU patients based on plasma syndecan-1 levels and other biomarker profiles.
• Analyzing associations between glycocalyx disruption and host response pathways like endothelial dysfunction, inflammation, and coagulation.
• Investigating the relationship between pathogen type and the degree of glycocalyx injury in bloodstream infections.
• Exploring transcriptomic signatures, such as hemostasis-related pathways, in patients with elevated syndecan-1.

Strengths

• Includes data from 188 ICU patients, with a subgroup of 142 patients having whole-blood transcriptome data.
• Measures 24 plasma biomarkers reflective of key pathophysiological domains in sepsis.
• Clinical outcomes, including 30-day mortality, are associated with biomarker levels.

Limitations

• Row count for the primary biomarker data is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small in scale at 562.9 KB, indicating limited data volume.

Provenance

Source

figshare

Collection Method

Biomarker measurements and transcriptome analysis from ICU patients with bacterial bloodstream infection.

Freshness

Last updated 2026-06-02 05:41:59; freshness should be verified.