Oropouche Virus Virulence Data in AG129 Mouse Model, 2023-2024

Experimental data from a study comparing the virulence of historical and contemporary Oropouche virus strains in the AG129 mouse model. The dataset likely contains measurements of viremia, viral loads in multiple organs, mortality rates, and cytokine responses. It was authored by Ellen Caroline Nobre Santos and uploaded to figshare in May 2026.

Use Cases

• Modeling viral pathogenicity based on mortality and disease progression data mentioned in the description
• Analyzing tissue-specific viral dissemination based on organ viral load data
• Studying the link between viral evolution and clinical severity based on comparisons between historical and reassortant strains

Strengths

• Data compares specific virus isolates (OROV_BeAn19991, OROV_SC2024, OROV_AC2024) with clear experimental outcomes.
• Includes measurements across multiple organs (spleen, kidney, liver, lung, uterus, testes, brain) and cytokine (IL-1β) data.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (672.1 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from laboratory infection of AG129 mice with Oropouche virus strains.

Time Range

Study focuses on contemporary isolates from 2023-2024 outbreaks.

Freshness

Last updated 2026-05-19 05:41:54; freshness should be verified.

Geography

Virus isolates are from non-Amazonian (SC2024) and Amazon Basin (AC2024) regions in South America.