In Vitro Study Data on Probiotic-Mediated Protection from Immunosuppressant Toxicity

A 936.8 KB PDF file authored by Tiziana Di Renzo and last updated in April 2026. The document contains research data from an in vitro study using differentiated CaCo-2 cells to model the intestinal barrier. The study investigates how a multistrain probiotic-conditioned medium can alleviate damage caused by mycophenolic acid and mycophenolate mofetil.

Use Cases

• Analyzing the effects of probiotic-conditioned medium on transepithelial electrical resistance based on the described permeability experiments.
• Modeling the protective role of postbiotics against cytotoxicity induced by immunosuppressant drugs like MPA and MMF.
• Investigating the expression of tight junction proteins (zonulin-1, claudin-5) in response to probiotic treatment and drug exposure.
• Studying the reduction of free oxygen radicals in cells exposed to pro-oxidant compounds as described in the research.

Strengths

• Data is associated with a specific, peer-reviewed research methodology using CaCo-2 cell transwell models.
• The file is licensed under CC-BY-4.0, permitting open sharing and adaptation.
• Research investigates multiple endpoints: barrier permeability, cytotoxicity, protein expression, and oxidative stress.

Limitations

• The primary data format is a PDF (936.8 KB); underlying tabular or raw experimental data may not be directly accessible.
• Row count and column-level documentation are unknown, limiting suitability assessment for direct computational analysis.
• The dataset scope is limited to a single, specific in vitro experiment.

Provenance

Source

figshare, author Tiziana Di Renzo

Collection Method

Experimental data from an in vitro laboratory study.

Time Range

The study period is not specified; the file was updated in 2026.

Freshness

Last updated 2026-04-14 05:10:17

Geography

Geographic origin of the research is not specified.