Supplementary file 1_Enteral nutrition versus immunomodulators for induction and maintenan

Supplementary file 1 from a systematic review and network meta-analysis comparing enteral nutrition and immunomodulators for pediatric Crohn's disease. The analysis includes 20 studies comprising 1,182 patients, with data sourced from PubMed, Embase, Cochrane CENTRAL, and Web of Science through October 2024. The document was authored by Jiajia Chen and last updated in April 2026.

Use Cases

• Compare treatment efficacy for remission induction based on odds ratios and SUCRA rankings detailed in the results.
• Assess treatment safety profiles based on reported serious adverse event rates for different therapies.
• Inform clinical guidelines for first-line induction therapy based on the network meta-analysis conclusions.
• Identify research gaps in pediatric Crohn's disease treatment by reviewing the included study designs and patient counts.

Strengths

• Includes data from 20 studies (7 RCTs, 13 observational) with 1,182 patients, providing a substantive evidence base.
• Reports specific statistical results, such as odds ratios with confidence intervals and SUCRA ranking values.
• Systematic review protocol was pre-registered with PROSPERO (CRD420261345561), indicating a structured methodology.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.
• The primary data file is a DOCX document, which may require parsing to extract structured data.

Provenance

Source

figshare

Collection Method

Systematic review and network meta-analysis of randomized controlled trials and comparative observational studies.

Time Range

Studies from database inception through October 2024.

Freshness

Last updated 2026-04-22 05:35:00; freshness should be verified.

Geography

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