Stress-Induced Phenotypic and Genomic Changes in E. coli and M. morganii from Ghana

Clinical and environmental strains of Escherichia coli and Morganella morganii from Ghanaian tertiary hospitals were exposed to extreme temperatures, pH, and osmotic stress. The exploratory study monitored growth kinetics, assessed persister-like cell formation under antibiotic challenge, and captured genomic changes via comparative whole genome sequencing. The work was authored by Tosin Yetunde Senbadejo and last updated in March 2026.

Use Cases

• Analyze bacterial growth kinetics under environmental stress based on OD600 and CFU determinations mentioned in the description
• Study the formation of persister-like cells under antibiotic challenge based on time-kill assays at 2 × MIC conditions
• Identify genomic adaptations to stress based on comparative whole genome sequencing of stress-recovered isolates
• Investigate links between environmental stress and antibiotic tolerance based on the phenotypic and genotypic changes described

Strengths

• Data includes comparative whole genome sequencing results for stress-recovered variants versus parental strains
• Study examines multiple stress conditions: temperature (~4°C and ~45°C), pH (3, 9, 10), and hyperosmolarity (1.71M NaCl)
• Licensed under CC-BY-4.0 for open reuse

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment
• The dataset is a single 84.1 KB DOCX file, suggesting limited scope and likely containing a manuscript rather than raw data
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

figshare

Collection Method

Clinical and environmental strains were exposed to controlled stress conditions, with growth monitored and genomic changes captured via sequencing.

Time Range

The study period is not specified.

Freshness

Last updated 2026-03-17 13:32:47

Geography

Strains were sourced from Ghanaian tertiary hospitals.