Supplementary File 1: Epigenetic Regulation of MAPKAPK2 in Vitiligo Melanocyte Model

A 153.5 KB DOCX file from figshare, authored by Yishan Wang and last updated in April 2026. This supplementary document details a study investigating the role of MAPKAPK2 in oxidative stress-induced damage in vitiligo melanocyte cell lines. The research employed cell lines PIG1 and PIG3V, with methods including qRT-PCR, Western blot, and functional assays.

Use Cases

• Analyzing the relationship between MAPKAPK2 expression and oxidative stress in melanocytes based on the described cell line model.
• Investigating epigenetic silencing mechanisms in vitiligo based on the described use of DNA demethylation agent 5-aza-DC.
• Studying the Nrf2/HO-1 antioxidant pathway activation based on the described experimental results.
• Validating cell viability and apoptosis assays under oxidative stress conditions based on the described functional experiments.

Strengths

• File is openly licensed under CC-BY-4.0.
• Description provides a detailed methodological account of the underlying study, including specific cell lines and assays used.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The 153.5 KB size indicates a very limited data scope, likely a single supplementary document.

Provenance

Source

figshare

Collection Method

Likely contains supplementary data and results from a laboratory study on vitiligo melanocytes.

Time Range

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Freshness

Last updated 2026-04-20 04:11:36; freshness should be verified.

Geography

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