Estrogen and Progesterone Modulation of CD4+ T-Cell Pathogenicity in Rheumatoid Arthritis

Supplementary file 1 from a study investigating the role of sex hormones in modulating CD4+ T cell responses in rheumatoid arthritis. The document, authored by Rohila Jha and shared under a CC-BY-4.0 license, details experiments measuring inflammatory markers, antibodies, hormone receptors, and cytokine expression in patient samples. The file was last updated on May 5, 2026.

Use Cases

• Analyzing the relationship between sex hormone levels and systemic inflammation markers described in the study.
• Investigating the heterogeneous patient responses to estrogen and progesterone stimulation based on cytokine and transcription factor modulation.
• Studying the expression of ERα and PR receptors on CD4+ T cells from rheumatoid arthritis patients versus controls.
• Examining the role of sex hormones in modulating RANKL and FasL expression, which are associated with bone erosion.

Strengths

• Dataset is associated with a specific, detailed research study on a defined clinical topic.
• File size is 1.9 MB, indicating a document with substantial descriptive content.
• Released under a permissive CC-BY-4.0 license, allowing for broad reuse.

Limitations

• The primary data format is a DOCX document, not a structured data file; column-level documentation is absent.
• Row count and sample size are unknown, which limits suitability assessment for quantitative analysis.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

Rohila Jha via figshare

Collection Method

Clinical study involving RA patients and controls; laboratory analysis of blood/synovial fluid samples and ex-vivo T cell stimulation.

Freshness

Last updated 2026-05-05 05:24:44; freshness should be verified.