Supplementary file 1_Evaluating the diagnostic and prognostic utility of serum DLL1 in acu

A dataset of serum Delta-like ligand 1 (DLL1) levels from a retrospective diagnostic study of 168 acute-on-chronic liver failure (ACLF) patients. The data was collected by Juanjun Huang and published on figshare under a CC-BY-4.0 license in May 2026. It includes measurements used to evaluate DLL1's diagnostic and prognostic utility for bacterial infections in this patient population.

Use Cases

• Train a binary classifier to predict bacterial infection status based on serum DLL1 levels.
• Build a diagnostic model combining DLL1 with C-reactive protein (CRP) to improve discriminative capacity.
• Analyze the correlation between DLL1 levels and hepatic function parameters to assess biomarker independence.
• Evaluate the clinical net benefit of using DLL1 for diagnosis via decision curve analysis simulation.

Strengths

• Data originates from a pre-established, prospectively maintained cohort of 168 ACLF patients.
• The study reports a significant diagnostic performance for DLL1 alone (AUC=0.815) and in a dual-marker model with CRP (AUC=0.852).
• The dataset is explicitly licensed for open use under CC-BY-4.0.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (158.0 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Retrospective analysis of a clinical cohort using enzyme-linked immunosorbent assays (ELISA).

Freshness

Last updated 2026-05-14 04:25:53; freshness should be verified.