In Vivo Cytokine Release Data for 19 Monoclonal Antibodies in Humanised Mice

Featuring in vivo cytokine release assessment data for a reference panel of 19 monoclonal antibodies with varying cytokine release potential. The data was generated from experiments using NOD-scid-gamma mice reconstituted with human CD34+ stem cells or peripheral blood mononuclear cells from healthy donors. The dataset supports comparative evaluation of engraftment forms and cytokine release patterns.

Use Cases

• Compare cytokine release patterns between HSC-engrafted and PBMC-engrafted humanised mouse models for the 19 monoclonal antibodies.
• Analyze the relationship between in vivo cytokine release data and previously established in vitro CR capacity from the same PBMC donor cohort.
• Evaluate the utility of humanised mouse models for hazard identification in preclinical safety assessment of biological therapies.

Strengths

• Data is derived from a standardized reference panel of 19 monoclonal antibodies, enabling comparative analysis.
• Includes in vivo assessment from two distinct humanised mouse model systems (HSC and PBMC engraftment).
• Published under a permissive CC BY 4.0 license, allowing for broad reuse and sharing.

Limitations

• The dataset is relatively small at 5.7 MB, which may limit the scope of complex statistical or machine learning analyses.
• Specific data structure, column definitions, and row counts are not provided, complicating immediate usability.
• Data is focused on a specific preclinical model system, which may limit direct translational insights without additional context.

Provenance

Source

figshare, authored by Deepa Rajagopal.

Collection Method

In vivo experimental assessment using NOD-scid-gamma mice reconstituted with human CD34+ stem cells or peripheral blood mononuclear cells.

Freshness

Last updated on 2026-03-20.