Hematocrit-Adjusted Drug Monitoring Data for Transplant Recipients

106.1 KB supplementary file details a study evaluating hematocrit-adjusted conversion strategies for mycophenolic acid (MPA) and tacrolimus (TAC) monitoring using volumetric absorptive microsampling (VAMS). The research, authored by Liang Juan, prospectively enrolled adult lung and renal transplant recipients to compare multiple Hct-adjusted approaches for MPA quantification against plasma and whole-blood samples.

Use Cases

• Compare hematocrit-adjusted conversion strategies for MPA concentrations between VAMS and plasma using Passing-Bablok regression and Bland-Altman analysis.
• Assess the correlation of TAC concentrations from VAMS with whole blood values without requiring Hct correction.
• Evaluate predictive performance metrics for different Hct-adjusted conversion approaches, such as Formula A-ind.
• Analyze scenario-based AUC estimations for MPA under different sampling schemes, comparing eight-point versus three-point VAMS sampling.

Strengths

• LC-MS/MS method validation shows good linearity (R² > 0.99) and accuracy within 85–115% across defined concentration ranges.
• The study systematically evaluates multiple Hct-adjusted conversion approaches for MPA, with one formula achieving 86% clinical agreement.
• Data supports the clinical applicability of a minimally invasive VAMS-based method for therapeutic drug monitoring of two key immunosuppressants.

Limitations

• The dataset is a 106.1 KB DOCX file, indicating a limited scope likely containing summary results and methodology rather than raw tabular data.
• Sample size and specific row/column counts for underlying data are unknown, limiting reproducibility and direct analytical use.
• Data is specific to adult lung and renal transplant recipients, which may limit generalizability to other transplant populations or pediatric patients.

Provenance

Source

figshare, author Liang Juan.

Collection Method

Prospective enrollment of adult transplant recipients; paired plasma, whole-blood, and VAMS samples analyzed via validated LC–MS/MS.

Time Range

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Freshness

Last updated March 26, 2026.

Geography

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