Beagle Dog Buccal Mucosa Repair Study: GT/PCL vs. ADM Nanofiber Membranes

12 beagle dogs were used to evaluate electrospun gelatin/polycaprolactone nanofiber membranes for repairing full-thickness buccal mucosal defects, with a comparative study against acellular dermal matrix membranes. The dataset, authored by Kun Song and shared under a CC-BY-4.0 license, includes results from macroscopic observations and histological assessments at postoperative days 7, 14, and 28. It was last updated on 2026-05-25.

Use Cases

• Compare wound healing efficacy between synthetic and biological scaffolds based on histological outcome measures.
• Analyze the relationship between neovascularization and scaffold type based on CD34-positive vessel counts.
• Evaluate early versus late-stage tissue remodeling based on collagen volume fraction and hydroxyproline content over time.
• Assess the impact of scaffold material on epithelial regeneration based on regenerated epithelium thickness measurements.

Strengths

• Data is derived from a controlled animal study with a stepwise bilateral self-paired design across 12 subjects.
• Includes quantitative histological assessments such as hydroxyproline quantification and collagen volume fraction.
• Provides a direct comparative analysis between two scaffold types (GT/PCL and ADM) at three specific time points.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is 8.0 MB, which is a small scale and may contain limited raw data.

Provenance

Source

figshare

Collection Method

Experimental study involving surgical creation of buccal mucosal defects in beagle dogs and subsequent histological analysis.

Freshness

Last updated 2026-05-25 22:01:46; freshness should be verified.