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A human research protocol involving 20 participants generated data for evaluating a real-time compensatory reserve measurement (CRM) algorithm. The CRM_RT application, developed in Python, processed photoplethysmography data streamed from a wearable pulse oximeter during simulated hypovolemia in a lower-body negative pressure chamber. The study, authored by Ryan Ortiz and last updated in April 2026, reports an average early prediction time of 18.3 minutes for hypovolemic decompensation.
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