Factors Affecting Voriconazole Trough Concentrations: A Dual-Center Retrospective Analysis

281 hospitalized patients receiving voriconazole were enrolled in a dual-center retrospective study. Demographic, liver and kidney function, C-reactive protein (CRP), and other clinical data were collected, with trough concentrations determined using HPLC. The dataset, authored by Feng Chen and last updated in April 2026, was used to identify factors influencing drug levels for dose optimization.

Use Cases

• Predicting supratherapeutic voriconazole concentrations based on C-reactive protein (CRP) levels mentioned in the description
• Modeling the effect of loading dose on trough concentration and toxicity risk as described in the results
• Identifying patient factors (weight, albumin, platelet count) influencing voriconazole pharmacokinetics from the clinical data
• Assessing the impact of concomitant medications (pantoprazole, dexamethasone) on drug levels as noted in the findings

Strengths

• Includes data from 281 patients, providing a basis for statistical analysis.
• Analyzes multiple clinical factors (CRP, liver function, weight, concomitant drugs) and their relationship to drug concentrations.
• Uses established analytical methods (HPLC) and statistical models (multivariate linear regression, ROC curves) as described.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (201.3 KB), indicating limited scope and likely a summary or supplementary document rather than raw patient records.

Provenance

Source

figshare

Collection Method

Retrospective analysis of clinical data from hospitalized patients.

Time Range

null

Freshness

Last updated 2026-04-23 04:21:30; freshness should be verified.

Geography

Dual-center study; specific locations unknown.