Fecal Amino Acid and SCFA Profiles in 60 Children with Migraine from Hebei, China

Ning Tian's 2026 study provides targeted metabolomics data from 60 fecal samples collected from 30 children with migraine and 30 healthy controls aged 5–14 years in Hebei Province, China. The dataset profiles amino acids, their derivatives, and short-chain fatty acids to identify metabolic signatures associated with pediatric migraine. It includes results of differential metabolite analysis, KEGG pathway enrichment, and ROC curve analysis for candidate biomarkers.

Use Cases

• Identify potential fecal metabolite biomarkers for pediatric migraine based on elevated amino acids like L-valine and L-phenylalanine.
• Analyze pathway enrichment related to valine, leucine, isoleucine, and phenylalanine biosynthesis from differential metabolite lists.
• Evaluate the preliminary discriminatory performance of candidate metabolites like tryptamine and 2,6-diaminopimelic acid using ROC curve data.
• Compare short-chain fatty acid profiles between pediatric migraine and control groups, noting described differences.

Strengths

• Includes data from a controlled clinical study with 60 samples (30 cases, 30 controls).
• Focuses on a specific pediatric population (aged 5–14 years) from a defined geographic region (Hebei Province, China).
• Applies targeted metabolomics to profile specific metabolite classes: amino acids, derivatives, and short-chain fatty acids.
• Provides analysis outputs including differential metabolites, KEGG pathway enrichment, and ROC curve results for candidate biomarkers.

Limitations

• The dataset is small in scale (674.2 KB), representing a single exploratory study.
• Row and column-level data are not described; the actual data structure must be inferred from the DOCX file.
• The description notes that most individual SCFA comparisons did not reach statistical significance, suggesting limited findings for that metabolite class.

Provenance

Source

figshare, author Ning Tian.

Collection Method

Targeted metabolomics profiling of fresh fecal samples from a cross-sectional clinical study.

Freshness

Last updated 2026-05-08 08:19:23.

Geography

Hebei Province, China.